Pressor effect of hypertonic saline on pulmonary circulation.
نویسندگان
چکیده
It has been suggested that the pressor effect of hypertonic solutions of sodium chloride on the pulmonary circulation results from spasm of the pulmonary veins at their junction with the left atrium. These studies demonstrate that the increased resistance in the pulmonary vessels develops upstream to this site and that it may result primarily from mechanical blockage of vessels by clumped erythrocytes rather than from vasoconstriction.
منابع مشابه
Site of action of hypertonic saline in the pulmonary circulation.
THE INTRAVENOUS INJECTION of 20 per cent saline to open-chest dogs has been shown to cause a marked though transient rise of pulmonary arterial pressure, attributed to spasm of the pulmonary arterioles.' Subsequently we demonstrated that the intravenous administration of hypertonic saline causes, in addition, a marked rise of pulmonary venous pressure and a fall or no change of left atrial pres...
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Dahl showed that feeding KCl prevents the rise in blood pressure caused by a high NaCl diet in salt-sensitive Dahl "S" rats. Such S rats when normotensive on a low NaCl diet have a 2 to 3 times greater pressor response than Dahl "R" rats to intracerebroventricular hypertonic saline (600 mOsm/liter) or angiotensin II (AII) (500 ng). Does dietary KCl prevent NaCl hypertension in S rats partly by ...
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عنوان ژورنال:
- Circulation research
دوره 7 شماره
صفحات -
تاریخ انتشار 1959